Structure Based Design of Non-Natural Peptidic Macrocyclic Mcl-1 Inhibitors
نویسندگان
چکیده
منابع مشابه
An evolutionary approach for structure-based design of natural and non-natural peptidic ligands.
A new computational approach (PEP) is presented for the structure-based design of linear polymeric ligands consisting of any type of amino acid. Ligands are grown from a seed by iteratively adding amino acids to the growing construct. The search in chemical space is performed by a build-up approach which employs all of the residues of a user-defined library. At every growing step, a genetic alg...
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ژورنال
عنوان ژورنال: ACS Medicinal Chemistry Letters
سال: 2017
ISSN: 1948-5875,1948-5875
DOI: 10.1021/acsmedchemlett.6b00464